The Human Of Human Genome Project - 995 Words

The Human Genome Project has been introduced to us more than twenty-five years from now. It was Initiated and sponsored by the National Human Genome Research Institute, the project was introduced aiming at researching more human genes in order to understand, read genes and find cure for diseases. It guided the medical field to new direction but at the same time created new challenges and problems. The primary objective of the project isn’t wrong or questionable but some believe its implications are. Genes are made of a molecule called DNA (deoxyribonucleic acid) which contains the instructions for making every protein in the body. By studying and understanding the genome system completely, we will be able to shed some light on how to†¦show more content†¦Carlos Cruchaga and his team searched for dementia-related genetic variations in some of these families and Their results were published in 2014 in the journals Nature and Nature Medicine. The team identified variatio ns in genes called phospholipase D3 (PLD3) and UNC5C that appear to promote the risk of late-onset Alzheimer’s disease. The results of what they found inspired them to keep looking for more. Dr. Cruchaga received his Association grant in 2011 for a study entitled Exome Sequencing of Late-Onset Alzheimer s Disease Families. Dr. Cruchaga selected 14 families to observe who have inherited Late-Onset Alzheimer. His team and him later analyzed the exomes from certain members of these families, searching for gene variations linked to Alzheimer’s. This process initially identified a variation in PLD3 that was shown to double the risk of Alzheimer’s disease in some cases. Previous research has found that people with Alzheimer’s tend to have lower than normal levels of the PLD3 protein in their brains. This finding indicates that PLD3 may protect the brain against Alzheimer’s-like changes. In 2005 there were various report on gene therapy trials delayed disease progression. It wasn t a successful cure, but the results were promising enough which triggered further research in that area. Scientists took skin cells from patients and modified them to secrete the protein nerve growth factor (NGF) form brains. These NGF producing